Friday, September 6, 2013

BRAIN EATING AMOEBA (NAEGLERIAFOWLERI)


EVER SINCE ITS DISCOVERY IN 1965,THE DIAGNOSIS IS DIFFICULT & MORTALITY CONTINUES TO BE HIGH.
WHAT CAN WE DO TO BRING DOWN MORTALITY?
THE FIRST PHYSICIAN WHO TREATS THE CHILD OR ADULT SHOULD ASK HIM SELF WHEATHER THE FOLLOWING POINTS CHECKED.

1,FEVER.
2,HEADACHE-ANTERIOR/POSTERIOR/TEMPORAL/EYEPAIN.
3,VOMITING/BLURRING OF VISION.
4,FITS ( SERIOUS).
5,NECK STIFFNESS (SERIOUS).
6,DECREBRATE SPASM (SERIOUS).
7,H/O SWIMMING IN POND/POOL/LAKE/UNDER WATER WARM WATER POOL.
8,SYMPTOMS WITHIN 2-5 DAYS AFTER SWIMMING.
9,H/O NASAL ASPIRATION OF SWIM WATER (SPREADS THROUGH OLFACTORY NERVE ENDING)
10 CAREFUL OBSERVATION &MASTERLY EXPECTANCY TO DO A LUMBAR PUNCTURE FOR CSF EXAM&IF NECESSARY REPEATED LPs.ONCE THE DIAGNOSIS IS CONFIRMED OR SUSPECTED TREATMENT SHOULD BE STARTED AS FOLLOWS ON A SCIENTIFIC CONCEPT.MANY DRUGS ARE USED FROM SULPHADIAZINNE /COLLOIDAL MERCURY TO NEWER DRUGS RIFAMPICIN ,AMPHOTRESIN-B/OTHER ANTI FUNGALS LIKE FLUCALAZOLE OR ANTI-BREAST CANCER DRUGS--ALL ARE ONLY EMPIRICAL &NOT PROOVEN.SO FOR ONLY SUCCESS RATEIS 10-20%.UNDER SUCH CIRCUMSTANSES
WHY NOT WE TRY ANY TWO OF THE FOLLOWING DRUGS?
1PRAZIQUENTAL
2RIFAMYCIN(ORAL/INTRA THECAL)
3)CHLOROQUIN-ORAL
4)METRANIDAZOLE-I.V

PRAZIQUENTAL
DRUG OF CHOICE TO TREAT NUERO CYTICERCOSIS. WITH CYSTIDE ORALLY.THIS IS DOCUMENTED IN TWO MEDICAL TEXT BO0OKS
ONE OF THE BEST ANTIPARASITIC IF BRAIN IS INVOLVED.DRUG ANAPHYLAXIS IS COMMON

CHOROQUIN
USED FOR CEREBRA MALERIA &TO KILL ENTAMAEBA HITOLYTICA.I.V USE IS DANGEROUSMAY RESULT IN SEVERE ANAPHYLAXIS

RIFAMYSIN
GOOD ANTI TB DRUG..FREQUENTLY USED FOR NEONATAL PYO-MENINGO ENCAPHALITIS.USED INTRATHECALLY VIA ANTRERIOR FONTENELLE
ANY OF THIS CAN BE USED DISSOLVING IN WATER ,GIVEN THRO NASOGASTRIC TUBE

METRANIDAZOLE
.USED FOR EH 7LATER FOR ANAEROBIC SEPSIS USED BY IVDRIP IS BETTER..ANY TWO DRUG THERAPY CAN BE USED ON ANA EXPERIMENTAL BASIS.THIS ONLY A CONCEPTUAL THINKING.

drselvarajp@yahoo.com-----ph;9841354335


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