Wednesday, November 26, 2008

AIDS-CONTINUED

AIDS-- CONTINUATION ..


103) HIV LIVING ON THE EDGE OF EXTINCTION
BUT FOR ITS SPREAD TO CITIES IN PERFECTION
DISEASE PREVENTION MOST IMPORTANT
'REUTERS'&'NATURES' REPORT PROVES POTENT.


104)AIDS PANDEMIC RESEARCHERS SAY
DUE TO GENETIC SEQUENCE OF HIV-1 GROUP-M ASSAY
MUTATIONS ACCUMULATE IN HIV ORIGIN
FIRST BEGAN SPREADING FROM 1908TO CARRY ON GENE


105)AIDS ANCESTORS 100 YEARS OLD
SPREAD VIA CHIMPANZEE HUMAN BOLD
HIV INFECTED PEOPLE 33 MILLION
HIV-KILLED PEOPLE 25 MILLION


106)ZIDAVUDINE &ACYCLOVIR FIRST
ZIDAVUDIN&INTERFERON ALPHA NEXT
ZIDA& I V IMMUNOGLOBULIN BEST
DRUG COMBINATION ESTABLISHED JUST.


107)MONTHLY IVIG PROLONGED SURVIVAL
ALSO INCREASED INFECTION FREE REVIVAL
PNEUMOCYSTIS CARNI TRIMETHOPRIME TREATED
SULPHA METHOXAZOLE COMBINATION BEST SUITED.


108)HIGH PCP PROPHYLAXIS FOR CHILDREN UNDER SIX
DEPENDING UPON AGE&T4 CELL COUNT DOSE FIXED
NEBULISATION WITH AEOROSOLISED PENTAMIDINE IS ALTERNATIVE
DAPSONE +TMP CONSIDERED SUPERLATIVE

Sunday, November 23, 2008

Case Report

Dr. P. Selvaraj

Consultant paediatrician,

S.R.M Speciality Hospital

RAMAPURAM.

Chennai – 89

TUBERCULOUS ACUTE ON CHRONIC LARYNGO TRACHEO BRONCHITIES

1. Abstract:-

A case of upper respiratory infection due to tuberculosis is presented. In children the usual manifestation is cough with ( or ) without fever and loss of appetite. This 12 year old child presented as whooping cough. Clinical, Radiological, Immnunological, findings along with family History, childs previous history, point towards tuberculous etiology.

2. Keywords

Primary complex, Mx Test, pertussoid cough, spasmodic cough, lymph node biopsy deseminated tuberculosis, TB Meningo encephalitis.

3. Introduction

In children primary complex is usually diagnosed by X- ray chest and Mantoux test along with clinical History of fever, cough and loss of appetite. This child presented as whooping cough, which is unusual in 12 year old child. The article aims at finding out etiopathologically, the causative agent with reasonable supportive findings.

4. Case Presentation

A 12 year old female child weighing (25 kg) looking very much with emaciated face and all four extremities. Presenting complaint was severe cough, spasmodic in nature, ending in the vomiting. Child used to get this 10-15 episodes perday. There was no other complaints, (or) positive physical findings during cough episodes except child’s supra sternal space indrawing was very unusually deep.

5. Previous History:-

Child had fever, cough, positive X- ray findings and treatment for primary complex with single drug regimen Rifamycin 3 years.

6. Family History:

Grand mother is having cough with productive sputum for last 10 years.

7. History of present illness:

Child was having cough and fever for 5 years since repeatedly. Diagnosed as primary complex and treated with Rifamycin. Cough subsided after 6 months. But the general condition went on deteriorating and now having pertussoide cough with frequent episodes in the last 6 months.

8. Clinical exam:

Thin looking individual. Throat NAD, Chest NAD, pertussoide cough still present and not amenable for conventional cough remedies. Has spasmodic cough suggestive of laryngo tracheo bronchitis. Chest clinically normal.

9. Investigations:

X- ray chest normal, mantaux test positive more than 25mm, TC – 8,000

DC

P- 42%

L-57%

E-1%

ESR – 1 hour 46mm

10. Discussion:-

Tuberculosis is still rampant in India, so the incidence of primary complex is also not reduced in the past 3 decades. Dr. P.M. udhani of Bombay was one person who has done maximum number of Histo pathological examination of tissues (lymphnodes mainly), from the paediatric patient’s of tuberculosis 4 decades back. He was only one in India who has made tissue pathological diagnosis in peadiatric tuberculosis to a maximum number. Primary complex can not only affect the pulmonary tissue but also lymphoid tissue in tonsils and the respiratory tract including soft palate, Vocal card, larynx, trachea, Bronchi, bronchioles and all regional lymphnodes and wherever there is increased lymphatic flow. Tuberculosis not only affect the respiratory system where it is known as primary complex in children. It also affect all other system in the body in peadiatric age group, most probably the central nervous system and the liver. In the yestear years disseminated tuberculous and tuberculous meningo encephalitis was often diagnosed. Now it is said to have reduced due to the use of B.C G vaccination. In the International scene India, Malaysia, Singapore, are practicing B.C .G Immunisation in the neonatal states.

1. The inability to eradicate tuberculosis in India is due to drug resistance type of organism (INH reistance)

2. B.C.G Vaccine in not prepared from INH resistant strains of AFB.

3. Pulmonary& tuberculosis with cavity, consolidation, atlectasis must be removed surgically & is being practiced only in the Armed forces India- (Lobectamy, segmental resection, plurectomy are all unheard in most Civil hospital practices) Children with laryngeal tuberculosis almost always have cavitary pulmonary diseases. ( Nelson) our case didn’t have cavitary lesion in lung.

Differential diagnosis:-

Any infection ( Virus/ Bacteria), growth, foreign body or any respiratory allergen, that causes branchial hyper reactivity (or) mucus membarane irritation anywhere is the larynx, trachea can cause this condition.

Bronchi & bronchioles can produce spasmodic pertussoid cough which may result in complete suffocation demanding emergency tracheostomy.

1. Diphtheria: Though the clinical picture is same in all the above pathological process this infection usually produces a membrane like picture over, Tonsils, cricoid, vocal cords, sometimes with haemorrhagic spots. If larynx is involved, tracheostomy often required.

2. H. Influenza Laryngitis: only throat swab can establish diagnosis

3. Viral: Usually acute in onset, preferably during epidemics with change of voice to brassy cough.

4. Pertussis: Age, history of non immunization & throat swab culture can clinch diagnosis. Typical cough in under 5 year child is often diagnostic.

Causative Viruses: Myxovirus, Para influenza

Type I: Measles Virus

Bacterial Agent: Strepto, Staphylo, H Influenza, Tubercle bacillus, : Except AFB all others generally produce acute symptoms. AFB can produce laryngo tracheal stenosis, causing repiratory stridar is a chronic disease with acute exacerbation now & then till disease is cured. When there is a scar in the trachea due to late treatment, symptoms may persist till surgical intervention which may cause further worsening.

Diagnosis:-

Following are positive findings towards diagnosis of this case.

1. Family History (grand mother) suffering from chronic pulmonary disease with productive cough even today since 10 years

2. Presently symptomatic with whooping cough like episode ending in vomiting

3. Clinically looks emaciated

4. Child’s chest X- ray & (primary complex – segmental collapse) taken 5 yrs back& treatment with Rifamycin for 3 yrs only with Rifamycin on & off is insufficient.

5. Mantaux test positive > 25mm now.

Case 2

50 yr old lady. In highly affluent society has cough on and off- 10 yrs, with more severity with expectorations – 5 yrs having spasmodic cough like whooping cough ending in vomiting after a repetitive succession of short coughs. Since – 1 month, not relieved by conventional therapy including steroids seen by well qualified super specialists. She was never investigated O/E Throat NAD looks healthy. Chest minimal wheeze x-ray chest : a) Rt interlobar effusion b) increased translucensy upper zones . c) completely opaque at lower zones sputum for AFB, Concentration method: AFB – positive 6n questioning father has PT being treated.

She was advised 1) inj SM – 45 2) ethambutol 600mg x OD 3. Rcin 600 x OD

The pertussoid cough is under control after 15 inj of SM + R cin + ET + Liv52

Discussion: Formerly all cases of haemoptysis were labelled as PT. Many inclined to see pertussoid cough as LTB of viral etiology & kock’s etiology often went unnoticed & unrecognized caseation is not noticed in our two cases. The author has not seen pertussoid cough in many cases of pulmonary caseation in military Hospital Aundh – Poona ( now military cardio – Thoracic center Golibar maiden Poona). Perhaps in the years to come, Acute on chronic LTB may be the order of the day for chronic Tuberculosis of Respiratory tract.

Treatment:

Being treated with following regimen

Inj. Streptomycin + Rifamycin + ethambutal + Pyrazinamide

(45 Injection)

Prognosis: Child is almost

50%Asymptomatic after 2 weeks therapy

Conclusion

Two cases of Acute on chronic laryngo tracheo bronchitis diagnosed based on family history presenting symptom & supportive radiographic findings. This is an unusual presentation of TB as LTB

Summary

Two cases of Tuberculosis or respiratory system presenting as LTB reported. The unusual findings in pertussoid cough in both cases. But for this they may not have met the doctor, who must be highly kock’s Conscious. In the child, positive mantoax, old X-ray & family history of TB were enough. In the adult X-ray, sputum & family history of TB were positive & enough to clinch the diagnosis. It is this authors personal experience that Inj. Streptomycin should be added to all cases of TB including primary complex if we don’t want future complications. The lesson learnt from these two cases in cough suppressants can work only upto certain limits. When the roof cause is not eradicated, cough will continue & take a different “avatar” – the pertussoid cough demanding for efficacious treatment.

References:

  1. Disease of the ear, nose throat:

Fourth editon, them ballentyne & Jhon Groves Bufferworths

  1. Short practice of otolaryngology – 3rd edition by prof KK Ramaligam et al ( page 276)
  2. Waldo E Nelson 14th edition 1992

Friday, November 21, 2008

Tips for practicing pediatricians

1)Be calm in a situation with a calamity.
2)patiently listen to parents version of ailment.
3)Do not jump into conclusions.
4)Take time to think.If required refer book quick..Give assurance that it can be cured
5) Also forget not to mention that it is God who makes final decision.
6)Tell your job is to "give medicine &bandage to the injury.It is God who heals the wound"
7)Some young kids may in an uncomfortable situation &end up in vomiting.
console the parents.SAY THIS MAY HABITUALLY RECUR.&NOT A CONCERN FOR WORRY.
8)In a sturdy 5 year old ,in an uncooperative child,venflon fixing may be extremely difficult..Try butter fly needle to give dose of diazapam ,i.v.to sedate,or wrap the child with a blanket to immobilise the lower extremities.Venesection may also be considered in a critical case like scorpion sting with peripheral circulatory failure.
There are many more tips.If required can consult me-mobile:9841354335.